There was clinical research conducted in Japan in which adipose-derived stem cells were used for hair loss regeneration or regrowth. One of the most recent discoveries in the cosmetic field is the ability to collect adipose-derived stem cells (ADSCs) from cytokines, which is a type of protein in blood cells. The cells were modified into ADSC-CM, which is a boosted state employing hypoxia. This means the removal of oxygen from the cells accelerates growth factors, making it more effective for hair loss treatment.

The method was made more advanced by using AAPE (Advanced Adipose-Derived Stem Cell Protein Extract) on individuals with hair loss. In simple terms, AAPE is the technique in which the adipose-derived stem cells are transformed into lyophilized forms. There is potential for this treatment to not only help patients with Alopecia but also other autoimmune and neurodegenerative hair loss that can be treated using this procedure.

This clinical trial was done on individuals, men, and women, who suffer from alopecia. The trial started with 3 to 4 ml of AAPE injections that were administered to the scalp area. The injections were administered once a month and had to be repeated 6 to 8 times. After the first 2 to 3 sessions, the results revealed fresh growth of thin hair on the scalp. With more treatments, new hair growth and hair in the anagen phase increased, and patients noticed more obvious positive effects with time.

Although the present technique of treatment can be uncomfortable for some patients because of the injections, the procedure continues to gain popularity among the Japanese. Many people have undergone AAPE for hair regrowth. This method uses a readily available formulation, and no special tools or equipment were involved during the therapy. This process is safe and can be called an effective approach. The results of this therapy are not immediate, but it does promote hair regeneration by rejuvenating the scalp. In a nutshell, adipose-derived stem cells have the potential to stimulate new hair growth.

Hair loss has serious psychological consequences, including lack of confidence and low self-esteem. To deal with it the traditional ways are no more convenient. Hair transplantation surgery is a more intrusive and expensive process for hair replacement, while oral medicines are slow healing and sometimes not effective. As a result, patients who do not notice substantial increases in hair growth through other treatments and oral medicines can turn to AAPE for hair regeneration treatment.